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Eur J Pharmacol. 1998 Jul 31;354(1):R13-4.

Topical ondansetron attenuates nociceptive and inflammatory effects of intradermal capsaicin in humans.

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Pain Clinic, HealthSouth Rehabilitation Hospital, Beaumont, TX 77707, USA.


Topical application of the 5-HT3 receptor antagonist ondansetron (50-250 microg) delivered in a pluronic lecithin organogel vehicle (PLO, 0.5 ml) produced dose-dependent attenuation of nociceptive and inflammatory effects of intradermally injected capsaicin (10 microg/10 microl) in humans. Significant, dose-dependent analgesic effects were produced by 100 microg and 250 microg doses of ondansetron; these doses also reduced mechanical hyperalgesia produced by capsaicin. However, only 250 microg dose of ondansetron diminished capsaicin-induced inflammatory flare.

[Indexed for MEDLINE]

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