Format

Send to

Choose Destination
See comment in PubMed Commons below
Histopathology. 1998 Jul;33(1):52-4.

Multiple synchronous lung cancers and atypical adenomatous hyperplasia in Li-Fraumeni syndrome.

Author information

  • 1Department of Surgery, Royal Brompton Hospital, London, UK.

Abstract

AIM:

We report a patient with Li-Fraumeni syndrome who developed multiple synchronous primary lung cancers together with atypical adenomatous hyperplasia, and discuss the pathogenesis of the lesions.

CASE DETAILS:

A 57-year-old woman with Li-Fraumeni syndrome and a history of smoking was diagnosed as having multiple synchronous primary lung tumours, all of which were treated by surgical excision. Histological examination showed three separate well-differentiated adenocarcinomas and a single focus of atypical adenomatous hyperplasia. A constitutional mutation of the p53 gene had been identified, both in this patient and other members of her family.

CONCLUSION:

Multiple synchronous primary lung tumours have not been reported before in association with this syndrome. With both smoking and Li-Fraumeni syndrome known to be associated with mutations in the p53 gene, a cumulative effect is suggested in this patient.

PMID:
9726049
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk