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Bioessays. 1998 Jul;20(7):523-7.

Tubulin and FtsZ structures: functional and therapeutic implications.

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  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.


The microtubule cytoskeleton has lagged nearly a decade behind the actin cytoskeleton with respect to structural information on the basic polymer subunit. This structural inferiority complex has finally been lifted by two recent papers describing the structures of the alpha beta tubulin dimer and FtsZ, a protein similar to tubulin that is essential for cell division in prokaryotes.

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