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Curr Opin Immunol. 1998 Aug;10(4):436-43.

Protective immunity induced by live attenuated simian immunodeficiency virus.

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Division of Immunology, New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.


Lack of information on the mechanisms of protective immunity to AIDS virus infection represents a major obstacle to the development of a rational strategy for an effective HIV vaccine. In macaques, immunization with live attenuated simian immunodeficiency viruses has induced the most potent protective immunity and continued study promises a better understanding of the nature of protective immune responses. Recent evidence supports involvement of both cytotoxic T lymphocytes and neutralizing antibodies in protective immunity against infection by simian immunodeficiency virus, but more detailed studies are needed to document their relative importance.

[Indexed for MEDLINE]

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