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Curr Opin Immunol. 1998 Aug;10(4):388-92.

Cross-clade T cell recognition of HIV.1.

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Department of Immunology, Chelsea and Westminster Hospital, London, UK.


Despite considerable advances in antiviral therapy for HIV infection, successful global intervention will require an effective vaccine. Current evidence suggests that cytotoxic T lymphocyte responses will be an important component of such vaccination. Recent evidence suggests that cytotoxic T lymphocytes raised against viral antigens from different clades (subtypes) of HIV.1 can cross-react extensively and such data have major implications for HIV vaccine design.

[Indexed for MEDLINE]

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