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Cell Biol Int. 1995 Dec;19(12):987-93.

Oxidative stress and the development of diabetic complications--antioxidants and lipid peroxidation in erythrocytes and cell membrane.

Author information

1
Department of Medical Bio-chemistry, PG Institute of Basic Medical Sciences, University of Madras, India.

Abstract

Erythrocytes isolated from 131 cases of Non-Insulin Dependent Diabetes Mellitus (NIDDM) were studied for lipid peroxidation, antioxidant defences, and the maximum peroxidisable substrate in the cell membrane. Antioxidant defences are lowered in NIDDM, followed by significant rise in lipid peroxidation products. However, in the erythrocyte membrane, the total polyunsaturated peroxidisable lipids are lower than in normal erythrocytes which may be a causative factor affecting the survival of the cells.

PMID:
9721623
DOI:
10.1006/cbir.1995.1040
[Indexed for MEDLINE]

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