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Science. 1998 Aug 28;281(5381):1312-6.

Caspases: enemies within.

Author information

1
Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA.

Abstract

Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

PMID:
9721091
DOI:
10.1126/science.281.5381.1312
[Indexed for MEDLINE]

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