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Yakugaku Zasshi. 1998 Jul;118(7):257-71.

[Function of DnaA protein, the initiator for chromosomal DNA replication in E. coli].

[Article in Japanese]

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  • 1Faculty of Pharmaceutical Sciences, Okayama University, Japan.


DnaA protein is an initiator for chromosomal DNA replication in E. coli. We have examined the function of the protein to answer the following four questions; 1. How DnaA protein is inactivated after DNA replication for the suppression of re-initiation? 2. How DnaA protein is activated for the initiation of DNA replication? 3. Does DnaA protein have functions other than that for DNA replication? 4. Is DnaA protein is a good target for new antibiotics? In this review, I summarize our recent studies for these questions.

[PubMed - indexed for MEDLINE]
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