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Curr Opin Biotechnol. 1998 Aug;9(4):366-9.

Structure-based drug design.

Author information

1
Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, Md. 21205, USA. mario@neruda.med.jhmi.edu

Abstract

Most of the techniques used in structure-based drug design have experienced significant improvements in the past few years, resulting in a marked enhancement of the speed and the efficacy of this approach. At the same time, it was thought that the future of drug design lay in strategies involving solely combinatorial chemistry. It is becoming evident, however, that the development of future drugs will use a combination of methods that will contain a major component of structure-based design.

PMID:
9720263
DOI:
10.1016/s0958-1669(98)80009-8
[Indexed for MEDLINE]

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