Format

Send to

Choose Destination
Am J Hum Genet. 1998 Sep;63(3):825-30.

Inheritance of astigmatism: evidence for a major autosomal dominant locus.

Author information

1
Servizio di Genetica Clinica ed Epidemiologica, Dipartimento di Pediatria, Universit√° di Padova, Italy. clementi@child.pedi.unipd.it

Abstract

Although astigmatism is a frequent refractive error, its mode of inheritance remains uncertain. Complex segregation analysis was performed, by the POINTER and COMDS programs, with data from a geographically well-defined sample of 125 nuclear families of individuals affected by astigmatism. POINTER could not distinguish between alternative genetic models, and only the hypothesis of no familial transmission could be rejected. After inclusion of the severity parameter, COMDS results defined a genetic model for corneal astigmatism and provided evidence for single-major-locus inheritance. These results suggest that genetic linkage studies could be implemented and that they should be limited to multiplex families with severely affected individuals.

PMID:
9718344
PMCID:
PMC1377402
DOI:
10.1086/302014
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center