Background: Some, but not all, patients undergoing radiation therapy for cancer experience depression. Recognition of depression in these patients is complicated by the effects of cancer, chemotherapy and radiation.
Methods: Total scores of the 30-item Inventory of Depressive Symptomatology-Self Report (IDS-SR) were used to divide 52 consecutive radiation oncology outpatients into those with depressive symptoms (n = 16) and those without (n = 36). These 2 groups were compared to find which depressive symptoms occurred and what risk factors were associated with them.
Results: Cognitive and endogenous, but not vegetative, symptoms of depression were helpful in distinguishing the 2 groups. A personal or family history of treated depression-but not the number of radiation treatments received-was also predictive of those with depressive symptoms.
Limitations: The patient population studied was small and diverse. Self-reports scores, rather than structured psychiatric interviews, were used to define clinically significant depression.
Conclusions: Depressive symptoms are not inevitable with cancer. Patient reports of thoughts of death or suicide, feeling restless, or diminished mood response to good events should prompt a more thorough evaluation for depression. A personal or family history of treated depression appears to be associated with an increased risk of depressive symptoms.