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Trends Cell Biol. 1998 Jul;8(7):282-8.

The AP-3 complex: a coat of many colours.

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Division of Cellular and Molecular Medicine, University of California, San Diego, La Jolla 92093-0668, USA.


A new adaptor protein complex, termed AP-3, has recently been identified in mammalian cells, and genetic studies in yeast have revealed a functional role for the AP-3 complex in cargo-selective transport via a new alternative trafficking pathway from the Golgi to the vacuole/lysosome. Here, the authors review what is currently known about the AP-3 complex and discuss recent insight into its function in multicellular organisms that has come from the finding that mutations in AP-3 subunits correspond to classical mutations in Drosophila and mice.

[Indexed for MEDLINE]

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