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Trends Cell Biol. 1998 Jul;8(7):272-6.

RAP, a novel type of ER chaperone.

Author information

1
Dept of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA.

Abstract

Members of the low-density lipoprotein (LDL) receptor gene family play an important role in cellular uptake of various extracellular ligands. Recent studies have shown that a 39-kDa protein known as RAP (receptor-associated protein) serves as a molecular chaperone to assist the folding of certain LDL-receptor family proteins and their passage through the secretory pathway. In this review, the authors discuss our current understanding of the roles of RAP as a molecular chaperone/escort protein and present a model of how RAP might carry out these functions.

PMID:
9714598
DOI:
10.1016/s0962-8924(98)01283-5
[Indexed for MEDLINE]

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