Format

Send to

Choose Destination
FEBS Lett. 1998 Jul 24;431(3):305-8.

Voltage gating is a fundamental feature of porin and toxin beta-barrel membrane channels.

Author information

1
Department of Biochemistry and Genetics, The Medical School, University of Newcastle Upon Tyne, UK.

Abstract

Beta-barrel pores are found in outer membrane porins of gram-negative bacteria, bacterial toxins and mitochondrial channels. Apart from the beta-barrel the three groups show no close sequence or structural homology but these pores exhibit symmetrical voltage gating when reconstituted into planar lipid bilayers. The structures of several of these are known and many site-directed mutants have been examined. As a result it seems evident that the gating is a common characteristic of these unrelated large pores and is not generated by specialised structures in the pore lumen.

PMID:
9714531
DOI:
10.1016/s0014-5793(98)00761-3
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center