Abstract
Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon deficiency. However, IL-2 mRNA levels in vivo did not reflect IL-2 production in vitro. Because IL-2 contributes to the pathogenesis of progressive leishmaniasis, the functional significance of these findings should be further explored.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cells, Cultured
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Disease Models, Animal
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Disease Progression
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Female
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Interferon-gamma / biosynthesis
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Interleukin-2 / biosynthesis*
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Interleukin-4 / biosynthesis
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Leishmania major / immunology*
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Leishmaniasis, Cutaneous / immunology*
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Leishmaniasis, Cutaneous / physiopathology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Spleen / cytology
Substances
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Interleukin-2
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Interleukin-4
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Interferon-gamma