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Circulation. 1998 Jul 28;98(4):290-3.

Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue.

Author information

1
Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA.

Abstract

BACKGROUND:

Our aim was to observe ultrasound-induced intravascular microbubble destruction in vivo and to characterize any resultant bioeffects.

METHODS AND RESULTS:

Intravital microscopy was used to visualize the spinotrapezius muscle in 15 rats during ultrasound delivery. Microbubble destruction during ultrasound exposure caused rupture of < or = 7-microm microvessels (mostly capillaries) and the production of nonviable cells in adjacent tissue. The number of microvessels ruptured and cells damaged correlated linearly (P<0.001) with the amount of ultrasound energy delivered.

CONCLUSIONS:

Microbubbles can be destroyed by ultrasound, resulting in a bioeffect that could be used for local drug delivery, angiogenesis, and vascular remodeling, or for tumor destruction.

PMID:
9711932
[Indexed for MEDLINE]

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