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Xenobiotica. 1998 Jul;28(7):617-61.

The CYP2 family: models, mutants and interactions.

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1
School of Biological Sciences, University of Surrey, Guildford, UK.

Abstract

1. The construction of three-dimensional models of mammalian cytochromes P450 from the CYP2 family is reported based on protein sequence alignment with CYP102, a bacterial P450 of known crystal structure. 2. The homology models of CYP2 family enzymes appear to show self-consistency with the currently accumulated information from site-directed mutagenesis and chemical modification of amino acid residues known to affect redox partner interactions. 3. The generation of these models from the recently reported crystal structure of substrate-bound CYP102 enables the exploration of likely active site contacts with specific substrates of CYP2 family isozymes.

PMID:
9711809
DOI:
10.1080/004982598239236
[Indexed for MEDLINE]
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