Benefit of screening mammography in women aged 40-49: a new meta-analysis of randomized controlled trials

J Natl Cancer Inst Monogr. 1997:(22):87-92. doi: 10.1093/jncimono/1997.22.87.

Abstract

Eight randomized controlled trials (RCTs) of screening mammography have been conducted involving women aged 40-49 at entry. Current data are now available from these trials at 10.5 to 18 years of follow-up (average follow-up time: 12.7 years). Meta-analysis has been performed using a Mantel-Haenszel estimator method to combine current follow-up data from the eight RCTs of mammography that included women aged 40-49 at entry, including new follow-up data presented at the NIH Consensus Development Conference held January 21-23, 1997. Combining the most recent follow-up data on women aged 40-49 at entry into all eight RCTs yields a statistically significant 18% mortality reduction among women invited to screening mammography (relative risk: 0.82; 95% confidence interval: 0.71-0.95). Combining all current follow-up data on women aged 40-49 at entry into the five Swedish RCTs yields a statistically significantly 29% mortality reduction among women invited to screening (relative risk: 0.71; 95% confidence interval: 0.57-0.89). Meta-analysis including the most recent follow-up data from all eight RCTs involving women aged 40-49 at entry demonstrates for the first time a statistically significant mortality reduction due to regular screening mammography in women of this age group.

Publication types

  • Meta-Analysis

MeSH terms

  • Adult
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / mortality
  • Breast Neoplasms / prevention & control*
  • Female
  • Humans
  • Likelihood Functions
  • Mammography*
  • Mass Screening / methods*
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Survival Rate