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FEBS Lett. 1998 Jul 17;431(2):134-7.

CH domains revisited.

Author information

1
Institute of Molecular Biology, Austrian Academy of Sciences, Department of Cell Biology, Salzburg.

Abstract

A sequence motif of about 100 amino acids, termed the 'calponin homology domain' has been suggested to confer actin binding to a variety of cytoskeletal and signalling molecules. Here we analyse and compare the sequences of all calponin homology domain-containing proteins identified to date. We propose that single calponin homology domains do not confer actin-binding per se and that the actin-binding motifs of cross-linking proteins, which comprise two disparate calponin homology domains, represent a unique protein module.

PMID:
9708889
DOI:
10.1016/s0014-5793(98)00751-0
[Indexed for MEDLINE]
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