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Cell. 1998 Aug 7;94(3):319-24.

Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.

Author information

1
Departamento de Anatomía y Biología Celular, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.

Abstract

Pitx2, a member of the bicoid-related family of homeobox-containing genes, is asymmetrically expressed in the left lateral plate mesoderm and derived tissues during chick and mouse development. Modifications of Pitx2 pattern of expression in the iv mouse mutation correlate with the situs alterations characteristic of the mutation. Misexpression experiments demonstrate that Shh and nodal positively regulate Pitx2 expression. Our results are compatible with a Pitx2 function in the late phase of the gene cascade controlling laterality.

PMID:
9708734
DOI:
10.1016/s0092-8674(00)81475-0
[Indexed for MEDLINE]
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