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Nucleosides Nucleotides. 1998 Jan-Mar;17(1-3):301-8.

Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein.

Author information

1
Department of Chemistry, Sheffield University, UK. g.m.blackburn@sheffield.ac.uk

Abstract

The design and synthesis of analogues of diadenosine 5',5"'-P1,P3-triphosphate that are resistant to pyrophosphate hydrolysis is described in relation to their rôle in signalling and tumorigenesis involving the Fhit protein, the human fragile histidine triad protein, which is a novel Ap3A binding/cleaving protein.

PMID:
9708352
PMCID:
PMC2556045
[Indexed for MEDLINE]
Free PMC Article

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