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Surgery. 1998 Aug;124(2):225-31.

Aspirin prevents tumors in a murine model of familial adenomatous polyposis.

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1
New York Hospital-Cornell University Medical Center, NY 10021, USA.

Abstract

BACKGROUND:

Both human and murine studies suggest that anti-inflammatory drugs prevent intestinal neoplasia. The purpose of this study was to investigate the role of aspirin as a chemopreventive agent for colorectal cancer.

METHODS:

We administered aspirin to the Min/+ mouse, an animal with a germline mutation in Apc, a gene that is essential for normal epithelial cell growth and differentiation. Apc mutation increases cytoplasmic beta-catenin, a regulatory protein associated with the cytoskeleton. Min/+ mice develop multiple intestinal adenomas and exhibit altered cell growth in the preneoplastic intestinal epithelium.

RESULTS:

Aspirin decreased the rate of tumor formation in Min/+ mice by 44%. Aspirin also normalized enterocyte growth by increasing apoptosis and proliferation in the preneoplastic intestinal mucosa. Finally, aspirin produced a decrease in intracellular beta-catenin levels, suggesting that modulation of this protein is associated with tumor prevention.

CONCLUSIONS:

These data confirm a role for aspirin in suppression of Apc-associated intestinal carcinogenesis.

PMID:
9706142
[Indexed for MEDLINE]

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