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Trends Cell Biol. 1998 Aug;8(8):302-5.

Nef--an adaptor adaptor?

Author information

1
Research Council, Laboratory for Molecular Cell Biology, University College, London, UK.

Abstract

The Nef protein of human immunodeficiency virus (HIV) is a crucial factor in viral pathogenesis. One of the roles of this multifunctional protein is to decrease the cell-surface expression of CD4, a component of the virus receptor complex, and of MHC class I molecules. New results indicate that Nef can link CD4 to endocytic clathrin adaptor complexes and might also modulate other steps in the endocytic pathway.

PMID:
9704405
DOI:
10.1016/s0962-8924(98)01318-x
[Indexed for MEDLINE]

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