Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 1998 Aug 14;281(5379):985-8.

Cholinergic switching within neocortical inhibitory networks.

Author information

1
Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, CA 94305, USA.

Abstract

Differential actions of acetylcholine on the excitability of two subtypes of interneurons in layer V of the rat visual cortex were examined. Acetylcholine excited low-threshold spike (LTS) cells through nicotinic receptors, whereas it elicited hyperpolarization in fast spiking (FS) cells through muscarinic receptors. Axons of LTS cells were mainly distributed vertically to upper layers, and those of FS cells were primarily confined to layer V. Thus, cortical cholinergic activation may reduce some forms of intralaminar inhibition, promote intracolumnar inhibition, and change the direction of information flow within cortical circuits.

PMID:
9703513
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center