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Bioessays. 1998 Jun;20(6):480-7.

Gene clusters and polycistronic transcription in eukaryotes.

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Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver 80262, USA.


Sometimes genes are arranged nonrandomly on the chromosomes of eukaryotes. This review considers instances of gene clusters in which two genes or more are expressed from a single promoter. This includes cases in which a polycistronic pre-mRNA is processed to make monocistronic mRNAs in nematodes, as well as isolated examples of polycistronic mRNAs found in mammals, flies, and perhaps plants.

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