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Bioessays. 1998 Jun;20(6):480-7.

Gene clusters and polycistronic transcription in eukaryotes.

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1
Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Denver 80262, USA. Tom.Blumenthal@uchsc.edu

Abstract

Sometimes genes are arranged nonrandomly on the chromosomes of eukaryotes. This review considers instances of gene clusters in which two genes or more are expressed from a single promoter. This includes cases in which a polycistronic pre-mRNA is processed to make monocistronic mRNAs in nematodes, as well as isolated examples of polycistronic mRNAs found in mammals, flies, and perhaps plants.

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