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Trends Biochem Sci. 1998 Jul;23(7):263-7.

N-terminal processing: the methionine aminopeptidase and N alpha-acetyl transferase families.

Author information

1
Dept of Physiology and Biophysics, College of Medicine, University of California, Irvine 92697, USA.

Abstract

Removal of the initiator methionine and/or acetylation of the alpha-amino group are among the earliest possible chemical modifications that occur during protein synthesis in eukaryotes. These events are catalyzed by methionine aminopeptidase and N alpha-acetyltransferase, respectively. Recent advances in the isolation and characterization of these enzymes indicate that they exist as isoforms that vary in cellular location, function, and evolutionary origins.

PMID:
9697417
DOI:
10.1016/s0968-0004(98)01227-4
[Indexed for MEDLINE]

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