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Trends Biochem Sci. 1998 Jul;23(7):239-42.

Getting knotted: a model for the structure and activation of Spätzle.

Author information

1
Dept of Biochemistry, University of Cambridge, UK.

Erratum in

  • Trends Biochem Sci 1998 Sep;23(9):361.

Abstract

Sequence analyses show that Spätzle, the Drosophila melanogaster Toll-receptor ligand, shows striking similarity to nerve growth factor and coagulogen. Comparative modelling suggests that Spätzle adopts a cystine-knot fold and forms a dimer that contains a single, intermolecular disulphide bridge. Proteolytically cleaved Spätzle could therefore dimerize and activate the Toll receptor by inducing receptor dimerization.

PMID:
9697410
DOI:
10.1016/s0968-0004(98)01216-x
[Indexed for MEDLINE]

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