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Trends Biochem Sci. 1998 Jul;23(7):236-8.

Protein-PCNA interactions: a DNA-scanning mechanism?

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Dept of Molecular Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.


Proliferating-cell nuclear antigen (PCNA) plays an essential role in nucleic-acid metabolism in all eukaryotes. The PCNA protein interacts with a large number of proteins. These proteins can be divided into two groups: the first contains proteins that have a known enzymatic activity; the second contains regulatory proteins that are involved in cell-cycle progression, checkpoint control and cellular differentiation. Interestingly, all of the enzymes known to interact with PCNA either recognize specific structures on DNA or have limited DNA-sequence specificity. Proteins that have low sequence specificities could utilize PCNA as an adapter in order to interact with their DNA substrates.

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