Format

Send to

Choose Destination
Trends Cell Biol. 1998 May;8(5):180-2.

The real LAT steps forward.

Author information

1
Cancer Research Fund, London, UK. cantrell@icrf.icnet.uk

Abstract

Antigen receptors initiate T-cell activation and determine the specificity of the immune response by activating membrane-localized protein tyrosine kinases. Signalling pathways initiated by these kinases control expression of the genes that mediate T-cell effector function. A major challenge in immunology is to work out the route taken by membrane-generated signals as they transit to the nucleus. Substrates for the ZAP70/Syk tyrosine kinases are important, but 'missing', links in this process. There has finally been some progress in characterizing one of these important linkers: LAT, an integral membrane protein that acts as an adaptor to couple antigen receptors to intracellular signalling cascades.

PMID:
9695835
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center