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Trends Cell Biol. 1998 Apr;8(4):133-7.

Atomic structures of tubulin and FtsZ.

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Dept of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

Erratum in

  • Trends Cell Biol 1998 May;8(5):210.


The recently published atomic structures of tubulin and FtsZ are a research milestone. The N-terminal GTP-binding domains of tubulin and FtsZ are virtually identical in structure, as expected from the substantial sequence identity. Sequence identity is absent from the C-terminal domains, but they also have virtually identical structures. A surprising finding is that the N-terminal GTP-binding domain is structurally homologous to that of Ras and other G proteins, despite the completely different GTP-binding sequence motifs. This article discusses these findings and the molecular mechanisms that can now be addressed with the atomic structures.

[Indexed for MEDLINE]

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