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Trends Cell Biol. 1998 Mar;8(3):116-20.

The caspase-RB connection in cell death.

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Dept of Biology, University of California, San Diego, La Jolla 92093-0322, USA.


Execution of the cell-death programme requires the activation of a family of cysteine proteases known as caspases. Specific cellular proteins are cleaved by caspases during apoptosis, including the retinoblastoma tumour-suppressor protein (RB1). A caspase-resistant RB1 can attenuate the death response to tumour necrosis factor alpha. The cleavage of RB1 during cell death, together with the increased cell death during embryonic development of Rb-knockout mice, suggests that RB1 degradation contributes to the activation of the cell-death pathway.

[Indexed for MEDLINE]

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