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Trends Cell Biol. 1998 Mar;8(3):111-5.

FH proteins as cytoskeletal organizers.

Author information

1
Dept of Molecular Biology and Oncology, UT Southwestern Medical Center, Dallas 75235-9148, USA. stevenw@hamon.swmed.edu

Abstract

Regulation of cell shape is a poorly understood yet central issue in cell biology. Recent experiments indicate that FH proteins link cellular signalling pathways to changes in cell shape. Members of the FH protein family play essential roles in cytokinesis and in driving alterations in cell polarity. This review discusses the structure and function of these proteins and examines the evidence that they interact specifically with Rho GTPases and profilin to organize the actin-based cytoskeleton.

PMID:
9695820
DOI:
10.1016/s0962-8924(97)01217-8
[Indexed for MEDLINE]

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