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Trends Cell Biol. 1998 Mar;8(3):97-8.

STATs as activators of apoptosis.

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Dept of Microbiology, Columbia University, NY 10032, USA.


STATs are a family of transcription factors that are activated in a ligand-dependent manner and promote the rapid induction of genes. They achieve this by directly transducing signals from the receptor into the nucleus. Consistent with their co-evolution with the cytokine family of ligands, studies have determined that STATs play a pivotal role in mediating the biological response for this family of ligands. However, STATs appear to have a dark side as well and contribute to programmed cell death. Intriguingly, a recent study suggests that this might occur in a manner that is distinct from the standard STAT signalling paradigm.

[Indexed for MEDLINE]

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