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Curr Opin Genet Dev. 1998 Jun;8(3):304-10.

Tumor suppressor mutations in mice: the next generation.

Author information

1
Massachusetts General Hospital Cancer Center, Charlestown 02129, USA. mcclatch@helix.mgh.harvard.edu

Abstract

Mouse strains carrying tumor suppressor mutations genetically mimic familial forms of human cancer. New tumor suppressors have and will be identified and mutated in the mouse; however, it is clear that future investigation will focus on a new generation of experiments aimed at improving existing models, and using them to delineate the molecular pathways to tumorigenesis and to test the value of rationally designed drug therapies.

PMID:
9690995
DOI:
10.1016/s0959-437x(98)80086-5
[Indexed for MEDLINE]

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