Send to

Choose Destination
Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9078-81.

Can ends justify the means?: telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells.

Author information

Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.


Finite replicative lifespan, or senescence, of mammalian cells in culture is a phenomenon that has generated much curiosity since its description. The obvious significance of senescence to organismal aging and the development of cancer has engendered a long-lasting and lively debate about its mechanisms. Recent discoveries concerning the phenotypes of telomerase knockout mice, the consequences of telomerase reexpression in somatic cells, and genes that regulate senescence have provided striking molecular insights but also have uncovered important new questions. The objective of this review is to reconcile old observations with new molecular details and to focus attention on the key remaining puzzles.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center