Format

Send to

Choose Destination
FEBS Lett. 1998 Jul 3;430(3):338-42.

Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis.

Author information

1
Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia. mauro.esposti@med.monash.edu.au

Abstract

Observations of apoptosis in virtual anaerobiosis have raised doubts on the significance of reactive oxygen species in the cascade of events of programmed cell death. This work presents evidence that cells and mitochondrial preparations produce similar levels of hydrogen peroxide under either aerobic or virtually anaerobic conditions. These levels are relevant to the increased production of radicals induced by a ceramide analog that promotes apoptosis. This ceramide acts at center o of mitochondrial complex III.

PMID:
9688567
DOI:
10.1016/s0014-5793(98)00688-7
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center