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Antimicrob Agents Chemother. 1998 Aug;42(8):2119-21.

Active efflux of norfloxacin by Bacteroides fragilis.

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1
Department of Microbiology, School of Dentistry, Aichi-Gakuin University, Nagoya 464-8650, Japan.

Abstract

Norfloxacin was actively pumped out by Bacteroides fragilis, which is intrinsically resistant to most fluoroquinolones. Reserpine moderately inhibited the efflux. A one-step spontaneous mutant had increased resistance to norfloxacin, ethidium bromide, and puromycin, a result suggesting that the efflux is catalyzed by a multidrug pump with specificity similar to that of NorA/Bmr.

PMID:
9687419
PMCID:
PMC105880
[Indexed for MEDLINE]
Free PMC Article
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