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Science. 1998 Jul 31;281(5377):670-2.

Peptides by activation of amino acids with CO on (Ni,Fe)S surfaces: implications for the origin of life.

Author information

1
Department for Organic Chemistry and Biochemistry, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.

Abstract

In experiments modeling volcanic or hydrothermal settings amino acids were converted into their peptides by use of coprecipitated (Ni,Fe)S and CO in conjunction with H2S (or CH3SH) as a catalyst and condensation agent at 100 degreesC and pH 7 to 10 under anaerobic, aqueous conditions. These results demonstrate that amino acids can be activated under geochemically relevant conditions. They support a thermophilic origin of life and an early appearance of peptides in the evolution of a primordial metabolism.

PMID:
9685253
DOI:
10.1126/science.281.5377.670
[Indexed for MEDLINE]
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