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FEBS Lett. 1998 Jul 10;431(1):7-11.

Mosaic Qbeta coats as a new presentation model.

Author information

1
Biomedical Research and Study Centre, University of Latvia, Riga.

Abstract

The new protein carrier was developed on the basis of recombinant RNA phage Qbeta capsid. C-terminal UGA extension of the short form of Qbeta coat, so-called A1 extension, served as a target for presentation of foreign peptides on the outer surface of mosaic Qbeta particles. In conditions of enhanced UGA suppression, the proportion of A1-extended to short coats in mosaic particles dropped from 48% to 14%, with an increase of the length of A1 extension. A model insertion, short preS1 epitope 31-DPAFR-35 of hepatitis B surface antigen, demonstrated superficial location on the mosaic Qbeta particles and ensured specific antigenicity and immunogenicity.

PMID:
9684855
DOI:
10.1016/s0014-5793(98)00716-9
[Indexed for MEDLINE]
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