Abstract
Gold appears to be the disease-modifying drug of first choice for two reasons: response and absence of long-term toxicity. Although cyclophosphamide produces results as good or better than gold, the possible long-term toxicity outweighs the clinical benefit except in the unusual case. Penicillamine appears to be an acceptable drug of second choice.
MeSH terms
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Arthritis, Rheumatoid / drug therapy*
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Cyclophosphamide / administration & dosage*
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Cyclophosphamide / therapeutic use
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Gold / administration & dosage*
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Gold / adverse effects
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Gold / therapeutic use
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Humans
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Penicillamine / administration & dosage*
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Penicillamine / adverse effects
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Penicillamine / therapeutic use
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Time Factors
Substances
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Gold
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Cyclophosphamide
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Penicillamine