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Radiother Oncol. 1998 May;47(2):125-8.

Testing for mutations of the ataxia telangiectasia gene in radiosensitive breast cancer patients.

Author information

1
Queensland Radium Institute Laboratory and Queensland Institute of Medical Research, Herston, Brisbane, Australia.

Abstract

BACKGROUND AND PURPOSE:

To determine if clinical radiosensitivity in breast cancer patients is related to mutations of the ataxia telangiectasia gene (ATM).

MATERIALS AND METHODS:

Fifteen patients who had developed a severe late reaction to a standard radiotherapy schedule were examined for evidence of increased in vitro radiosensitivity using the MTT assay. Mutation analysis was performed using a protein truncation assay.

RESULTS:

No mutations were detected in the 15 patients despite evidence of increased in vitro radiosensitivity.

CONCLUSIONS:

Testing for the ATM gene is unlikely to be useful for predicting clinical response to radiotherapy in breast cancer patients.

PMID:
9683358
[Indexed for MEDLINE]

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