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Neuropharmacology. 1998;37(2):273-6.

A modulatory effect of extracellular Ca2+ on type 1alpha metabotropic glutamate receptor-mediated signalling.

Author information

1
Department of Cell Physiology and Pharmacology, University of Leicester, UK.

Abstract

Increasing [Ca2+]e from 1.3 4 mM had little effect on basal phospholipase C activity in baby hamster kidney (BHK) cells stably expressing either type 1alpha metabotropic glutamate (mGlu1alpha) or M3-muscarinic (m3) receptors, but enhanced agonist-stimulated phosphoinositide hydrolysis in BHK-mGlu1alpha, but not BHK-m3 cells, demonstrating that Ca2+(e) selectively modulates phosphoinositide signalling stimulated by this receptor subtype.

PMID:
9680253
DOI:
10.1016/s0028-3908(98)00027-6
[Indexed for MEDLINE]

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