Send to

Choose Destination
Diabetes Metab Rev. 1998 Jun;14(2):171-5.

Role of endothelin-1 in diabetes mellitus.

Author information

Semmelweis Medical University 2nd and 1st Internal Medicine Department, Budapest, Hungary.


Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center