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Diabetes Metab Rev. 1998 Jun;14(2):171-5.

Role of endothelin-1 in diabetes mellitus.

Author information

1
Semmelweis Medical University 2nd and 1st Internal Medicine Department, Budapest, Hungary.

Abstract

Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.

PMID:
9679669
[Indexed for MEDLINE]

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