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FEBS Lett. 1998 Jun 23;430(1-2):73-7.

The thermosome: archetype of group II chaperonins.

Author information

1
Max-Planck-Institut für Biochemie, Martinsried, Germany.

Abstract

The thermosome, the chaperonin of the archaea, and its homologue from the cytosol of eukaryotes, known as TRiC or CCT, form a distinct subfamily of the chaperonins that does not depend on a co-chaperonin for protein folding activity. Recent structural data obtained by cryo- electron microscopy and X-ray crystallography provide the first insights into a novel mechanism remarkably different from that of the bacterial GroEL-GroES system.

PMID:
9678597
DOI:
10.1016/s0014-5793(98)00541-9
[Indexed for MEDLINE]
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