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FEBS Lett. 1998 Jun 23;430(1-2):37-40.

G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions.

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Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Cientifícas-Universidad Autónoma de Madrid), Spain.


G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.

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