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FEBS Lett. 1998 Jun 23;430(1-2):37-40.

G protein-coupled receptor kinase 2 (GRK2): mechanisms of regulation and physiological functions.

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1
Departamento de Biología Molecular, Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Cientifícas-Universidad Autónoma de Madrid), Spain.

Abstract

G protein-coupled receptor kinase 2 (GRK2) plays a key role in determining the rate and extent of G protein-coupled receptor (GPCR) desensitization and resensitization. Recent data indicate that GRK2 activity, subcellular distribution and expression are tightly regulated. The important physiological function of GRK2 as a modulator of the efficacy of GPCR signal transduction systems is exemplified by its relevance in cardiovascular physiopathology as well as by its emerging role in the regulation of chemokine receptors.

PMID:
9678590
[Indexed for MEDLINE]
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