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FEBS Lett. 1998 Jun 23;430(1-2):28-36.

The complete genome of Bacillus subtilis: from sequence annotation to data management and analysis.

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Unité de Régulation de l'Expression Génétique, Institut Pasteur, Paris, France.


The completion of the entire 4.2-Mb genome sequence of the gram-positive bacterium Bacillus subtilis has been a milestone for biological studies on this model organism. This paper describes bioinformatics work related to this joint European and Japanese project: methods and strategies for gene annotation and detection of sequencing errors, using an integrated cooperative computer environment (Imagene); construction of a specialized database for data management and a WWW server for data retrieval (SubtiList); DNA sequence analysis, yielding striking results on oligonucleotide bias, repeated sequences, and codon usage, all landmarks of evolutionary events shaping the B. subtilis genome.

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