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Cytogenet Cell Genet. 1998;80(1-4):222-5.

X-linked sex-reversing genes.

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Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103, USA.


Rearrangement of the X chromosome generates fertile XY females in the wood lemming, and a duplication has been discovered in Xp21 in some XY females in the human. This has enabled identification and mapping of a novel sex-reversing gene in the human, double dosage of which blocks development of the testis. Whether or not the human gene is related to the gene that causes sex reversal in the wood lemming remains to be seen. Yet similar genes must exist in all eutherian mammals, according to Ohno's Law.

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