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Minerva Ginecol. 1998 May;50(5):207-11.

[Treatment of neurovegetative menopausal symptoms with a phytotherapeutic agent].

[Article in Italian]

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Istituto di Ginecologia e Ostetricia, Università degli Studi-Siena.



Menopausal symptoms include hot flushes, insomnia, nocturnal sweating, dizziness, headaches and palpitations. These symptoms reflect adaptation of the body to estrogen deprivation which affects various central neurotransmitters.


In this study, the efficacy has been tested of a plant product based on extracts of the leaves of Salvia officinalis (sage) and Medicago sativa (alfalfa) in the treatment of hot flushes in 30 menopausal women with these symptoms.


Hot flushes and night sweating completely disappeared in 20 women: four women showed good improvement and the other six showed a reduction in symptoms. GnRH and TRH tests were performed in 8 women to evaluate TSH and Prl responses before and after 3 months of therapy. The plants product induced a significant increase in Prl and TSH response to TRH. Basal levels of estradiol, LH, FSH, Prl and TSH were unchanged.


The product seams to have a central slight antidopaminergic action without side effects and is an effective agent in the treatment of menopausal symptoms.

[Indexed for MEDLINE]

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