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Biomaterials. 1998 Mar;19(4-5):327-39.

Investigation of interactions between antimicrobial agents and bacterial biofilms using attenuated total reflection Fourier transform infrared spectroscopy.

Author information

1
Center for Biofilm Engineering, Montana State University, Bozeman 59717, USA.

Abstract

Biomaterial-centred infections are often difficult to treat. An impaired immune response, acute inflammatory reactions and the presence of recalcitrant attached microorganisms are all contributing factors. A brief review of the role of attached bacteria in biomaterial-centred infections is presented. Two major hypotheses which may explain the recalcitrance of biofilms to antimicrobial agents are discussed. The analytical capabilities of attenuated total reflection Fourier transform infrared (ATR/FTIR) spectroscopy for providing information on both transport of an antimicrobial agent to bacteria embedded in the biofilm and interactions between an antimicrobial agent and biofilm components are described.

PMID:
9677148
DOI:
10.1016/s0142-9612(97)00108-7
[Indexed for MEDLINE]

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