Format

Send to

Choose Destination
Clin Infect Dis. 1998 Jul;27(1):23-7.

The pharmacodynamics of aminoglycosides.

Author information

1
Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, USA.

Abstract

Recently, a more complete understanding of the pharmacodynamics of aminoglycosides has been recognized, indicating that this class of antibiotics exhibits both concentration-dependent bactericidal activity and a postantibiotic effect. This pharmacodynamic information, along with better knowledge of the mechanisms responsible for aminoglycoside toxicity, established the foundation for once-daily aminoglycoside dosing regimens. This new approach to aminoglycoside dosing appears to be safe, efficacious, and cost-effective, resulting in its increasing popularity in clinical practice.

PMID:
9675444
DOI:
10.1086/514620
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center